Abstract 2773 Ergosterol-binding sponge assembly elucidates natamycin fungicidal activities

Natamycin, a glycosylated polyene macrolide (GPM), is widely used as an antifungal agent in food preservation, particularly in dairy products, and as a treatment for fungal eye infections. While ergosterol has been established as natamycin's therapeutic target, the structural mechanisms underlying ergosterol binding and extraction remain poorly understood. Recent bioinformatics analysis suggests that natamycin, like amphotericin B, self-assembles into a