Abstract 2191 Characterization of Heparin Interactions with Recombinant Rodent Stabilin-2/Hyaluronic Acid Receptor for Endocytosis (HARE)
Introduction: Stabilin-2 is the primary scavenger for hyaluronan (HA) and binds to over two dozen other ligands including chondroitin sulfates, heparin, oxidized/acetylated LDL, etc. Although rat liver sinusoidal endothelial cells are the preferred primary cell lines and animal for physiological studies of Stab2/HARE, the rat recombinant protein has never been characterized. Since the rat Stab2/HARE has a high degree homology to mouse Stab2/HARE which has been cloned, our hypothesis is that the rat receptor is identical to mouse and very similar to the human receptor.
Authors
- Reed Rohr
- J.F. Staab
- Edward N. Harris (ORCID: https://orcid.org/0000-0001-7045-1040)
- Jeffrey E. McWilliams
- Linda Fatumoju
- Grant Hatcher
- Abby Bopp
- Callan Shroder
Institutions
- University of Nebraska–Lincoln (US)
Publication Details
- Journal
- Journal of Biological Chemistry
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1016/j.jbc.2025.109061
- Primary Topic
- Monoclonal and Polyclonal Antibodies Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00