Abstract 2401 Development of a genetically-encoded biosensor to investigate glutamine metabolism with high spatiotemporal resolution

Glutamine, the most abundant amino acid in serum, is involved in numerous biological processes. Many cancers heavily rely on glutamine, consuming it rapidly to sustain oxidative phosphorylation and biosynthesis of various essential molecules such as nucleotides, lipids, and glutathione. Furthermore, glutamine starvation is fatal in some cancer cell lines. The importance of glutamine metabolism in cancer has long been appreciated, making it an attractive target for therapeutic interventions. However, current therapeutics that target glutamine metabolism are limited.