Abstract 1566 Title: Targeting quorum sensing signal production in Chromobacterium subtsugae

Morbidity and mortality rates continue to rise for hospital-acquired infections, highlighting our need to combat increasingly antibiotic-resistant strains. One way to approach antibiotic resistance involves the disruption of quorum sensing (QS) in bacteria. QS is utilized by both Gram-positive and Gram-negative bacteria. The pathway mediates cell-to-cell communication to regulate energetically-costly behaviors such as biofilm formation, motility and production of virulence factors, which enable bacteria to colonize a host.