Proteomic and metabolomic analysis of platelet related samples reveals energy metabolism disorders in hepatocellular carcinoma
Through multi-omics characterization of platelets-related samples, the network of altered proteins and metabolites provides a comprehensive view of altered metabolism in the peripheral circulation of HCC patients. Gln deprivation inhibited the ability of platelet-induced malignant biology function in HCC cells. Collectively, proteomics and metabolomics provide evidence for possible future non-invasive or minimally invasive biopsies for patients with HCC.
Authors
- H. Wang
- Zuojian Hu (ORCID: https://orcid.org/0000-0003-4695-1189)
- Xuelian Ruan (ORCID: https://orcid.org/0000-0002-2303-4217)
- Yongling Chen
- Fenglin Shen (ORCID: https://orcid.org/0000-0003-2120-2077)
- Guiyong Ou
- Xing Luo
- Xue Qin (ORCID: https://orcid.org/0000-0002-4513-3515)
- Ziqing Zhong
Institutions
- Guangxi Medical University (CN)
- Fudan University (CN)
- The People's Hospital of Guangxi Zhuang Autonomous Region (CN)
- Guangxi Zhuang Autonomous Region Brain Hospital (CN)
- First Affiliated Hospital of GuangXi Medical University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-06-13
- DOI
- https://doi.org/10.1186/s12967-025-06694-x
- Citations
- 2
- Primary Topic
- Cancer, Lipids, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 1.87
Funders
- National Natural Science Foundation of China
- Ministry of Science and Technology of the People's Republic of China
- Natural Science Foundation of Guangxi Province
- Division of Graduate Education