Abstract 2277 Gut microbiota-derived metabolite Trimethylamine N-oxide alters the host epigenome through inhibition of S-adenosylhomocysteine hydrolase

Trimethylamine N-oxide (TMAO), a metabolite derived from gut microbiota, is produced from dietary choline, carnitine, and phosphatidylcholine. It has been implicated in the progression of inflammatory and metabolic diseases. Prior studies in gnotobiotic mice revealed that colonization with choline-consuming bacteria leads to elevated systemic TMAO levels when fed a high-choline diet. These mice exhibited reduced DNA methylation across various tissues compared to genetically modified counterparts incapable of producing TMAO.