MGE- <i>Acr</i> Clusters in <i>Pseudomonas aeruginosa</i> Clinical Isolates
Background: Mobile genetic elements (MGEs) play an important role in the pathogenicity of bacteria and are regulated by mechanisms such as CRISPR-Cas systems. In response, MGEs encode CRISPR-Cas antagonists, known as anti-CRISPR (Acr), contributing to their spread. Methods: Here, we performed genomic analysis of 128 P. aeruginosa clinical isolates to determine the presence of CRISPR-Cas systems, MGEs and Acrs.
Authors
- Inés Bleriot (ORCID: https://orcid.org/0000-0002-1846-4693)
- Antonio Barrio-Pujante (ORCID: https://orcid.org/0009-0006-8173-0823)
- María Tomás (ORCID: https://orcid.org/0000-0003-4501-0387)
- Rafael Cantón (ORCID: https://orcid.org/0000-0003-1675-3173)
- Laura Fernández-García (ORCID: https://orcid.org/0000-0002-8531-6105)
- Concha Ortiz-Cartagena (ORCID: https://orcid.org/0000-0001-6632-1454)
- Antonio Oliver (ORCID: https://orcid.org/0000-0001-9327-1894)
- Lucía Blasco (ORCID: https://orcid.org/0000-0002-4039-4142)
- Carla López-Causapé (ORCID: https://orcid.org/0000-0003-2228-2005)
- Lucía Armán (ORCID: https://orcid.org/0009-0008-6209-327X)
- Clara Ibarguren
Institutions
- Universidade da Coruña (ES)
- Instituto de Salud Carlos III (ES)
- Centro de Investigación Biomédica en Red (ES)
- Fundación Seimc-Gesida (ES)
- Health Research Institute of the Balearic Islands (ES)
- Instituto Ramón y Cajal de Investigación Sanitaria (ES)
- Complexo Hospitalario Universitario A Coruña (ES)
- Hospital Universitario Son Espases (ES)
- Instituto de Investigación Biomédica de A Coruña (ES)
- Hospital Universitario Ramón y Cajal (ES)
Publication Details
- Journal
- DNA and cell biology reports.
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1089/dcbr.2025.0027
- Citations
- 1
- Primary Topic
- Bacteriophages and microbial interactions
- Type
- article
- Field-Weighted Citation Impact
- 1.72