Longitudinal Imaging Reveals Tumor Uptake and Prolonged Retention of Bispecific T Cell–Engaging Antibody in GBM via Passive and Active Mechanisms
Our findings provide critical insights into the pharmacokinetics of BTE molecules in GBM. They demonstrate effective penetration and prolonged intratumoral retention following a single systemic dose, supporting further exploration of BTE treatment regimens for translation to clinical settings.
Authors
- Yutian Feng (ORCID: https://orcid.org/0000-0002-2222-1619)
- Irina V. Balyasnikova (ORCID: https://orcid.org/0000-0002-4664-9441)
- David Siegel (ORCID: https://orcid.org/0000-0001-5314-1622)
- Michael R. Zalutsky (ORCID: https://orcid.org/0000-0002-5456-0324)
- Rebecca Meshaw
- Ashlynn Barnes (ORCID: https://orcid.org/0000-0002-4041-9733)
- Truc T. Huynh (ORCID: https://orcid.org/0000-0001-6423-6715)
- Ángela Martín‐Regalado (ORCID: https://orcid.org/0000-0003-4891-5499)
- Joseph Duffy (ORCID: https://orcid.org/0000-0002-7895-3966)
- Aditi Thakur
- Dmitri Simberg (ORCID: https://orcid.org/0000-0002-5288-6275)
- Benedikt Haupt
- A. Alzeer
Institutions
- Northwestern University (US)
- Duke University (US)
- Duke Medical Center (US)
- Robert H. Lurie Comprehensive Cancer Center of Northwestern University
- University of Colorado Anschutz Medical Campus (US)
- University of Montana (US)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2025-06-13
- DOI
- https://doi.org/10.1158/1078-0432.ccr-24-4194
- Citations
- 1
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 1.05