Abstract 3056 Shared genetic architecture across uterine fibroids and keloids

Keloid scars and uterine leiomyomata, or uterine fibroids, are benign fibroproliferative disorders hypothesized to share genetic etiology. Despite their disparate anatomy and pathology, these conditions are frequently comorbid and are both characterized by uncontrolled cell proliferation and overgrowth of connective tissue. They are also both highly heritable and have similar differences in prevalence across geographic populations. We aimed to investigate the shared genetic architecture of keloids and fibroids, leveraging both multi-ancestry and ancestry-stratified summary statistics from recent genome-wide association study (GWAS) meta-analyses.