Abstract 1570 Elucidating the Potential Feedback Mechanism Between PIK3C3 and TBC1D2 in Oligonucleotide Drug Delivery

Elucidating the Potential Feedback Mechanism Between PIK3C3 and TBC1D2 in Oligonucleotide Drug Delivery Linda B. Fatumoju, Edward N. Harris. Department of Biochemistry, University of Nebraska, Lincoln NE 68588, USA. [email protected] Abstract Effective therapeutic outcomes of oligonucleotide drugs are hindered by the challenge of delivering these molecules efficiently, necessitating their escape from late endosomes prior to lysosomal degradation. Our previous studies have identified Stabilin receptors as key mediators of phosphorothioate antisense oligonucleotides (PS-ASOs) internalization in liver sinusoidal endothelial cells.