Abstract 1539 Modeling the Binding of Five Selective Serotonin Reuptake Inhibitors (SSRIs) to the Human Serotonin Transporter (hSERT) to Allosteric and Central Binding Sites

Modeling the Binding of Five Selective Serotonin Reuptake Inhibitors (SSRIs) to the Human Serotonin Transporter (hSERT) to Allosteric and Central Binding Sites A staggering 21 million people are currently affected by Major Depressive Disorder (MDD), a condition that can impact an individual's ability to complete even the most basic everyday activities. Serotonin is a neurotransmitter which is taken back to nerve cells through a process called reuptake. However, Selective Serotonin Reuptake Inhibitor, (SSRIs), block this process, therefore making more serotonin available to help promote communication in the brain.