Abstract 1785 Mechanisms of VEGF Receptor Trafficking Dynamics and Regulation

Vascular endothelial growth factor (VEGF) controls the growth and regression of blood vessels. While some successes have been achieved in inhibition of VEGF to disrupt blood vessel growth in cancer and retinopathy, over a dozen clinical trials of VEGF delivery to increase vascular growth in patients with ischemic diseases have failed. The inability to successfully bridge treatment from animals to humans demonstrates that our understanding of the VEGF system is far from complete. We have developed and validated a molecularly-detailed computational model of VEGFR1, VEGFR2, and Neuropilin-1 trafficking in endothelial cells.