The purinergic receptor P2rx7 mediated ATP sensing is required to prevent bone aging by directing mitochondrial fitness of MSCs
Taken together, our results highlight a role for P2rx7 in regulating mitochondrial dynamics coordinates with ERK pathway, thereby highlighting P2rx7 as a promising target to rejuvenate the tissue aging.
Authors
- Ruili Yang (ORCID: https://orcid.org/0000-0001-6347-3196)
- Liujing Chen (ORCID: https://orcid.org/0000-0003-0474-4114)
- Zimeng Zhuang
- Shuai Lin (ORCID: https://orcid.org/0000-0002-4089-5721)
- Meilian Cai
- Zilu Zhu (ORCID: https://orcid.org/0000-0002-1944-0108)
- Chunshan Han
- Han Zhang (ORCID: https://orcid.org/0000-0002-0166-1973)
- Bing Han (ORCID: https://orcid.org/0000-0003-3037-6028)
- Mingzhao Li (ORCID: https://orcid.org/0009-0003-9216-6680)
- Chenyang Xing
Institutions
- Stomatology Hospital (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2025-06-13
- DOI
- https://doi.org/10.1016/j.jare.2025.06.026
- Citations
- 1
- Primary Topic
- Adenosine and Purinergic Signaling
- Type
- article
- Field-Weighted Citation Impact
- 1.12
Funders
- National Natural Science Foundation of China
- Ministry of Education of the People's Republic of China
- Peking University
- National Key Research and Development Program of China
- Fundamental Research Funds for the Central Universities