Abstract 1597 Stability and function of a Salmonella copper resistance protein with changes to a linker region

Copper ions are used in a variety of ways for their antimicrobial properties. However, bacteria can resist copper's antimicrobial properties by using a number of mechanisms. In Salmonella enterica, a protein named DcrB aids in copper resistance. Previous research indicates that mutating two residues in DcrB in a region that links a small N-terminal beta hairpin to its core structure causes the protein to have decreased function. The overall goal of this research is to better understand how the protein DcrB functions in copper resistance.