Abstract 1032 Turning the Oxygen and Vitamin Dials

Oxygen deprivation (hypoxia) and excess (hyperoxia) are both toxic to humans. Oxygen deprivation contributes to 3 of the 5 leading causes of mortality in developed nations -- heart attack, stroke, and respiratory failure. On the other hand, hyperoxia is toxic to nearly all organisms and contributes to the pathology of ischemia-reperfusion injury, mitochondrial disease and hyperoxic lung injury. However, the molecular mechanisms underlying hypoxia and hyperoxia toxicity remain unknown. By deciphering these mechanisms, we strive to nominate novel therapeutic candidates.