Abstract 1592 Hepatic Mitochondrial-Derived Oxysterols Link Mash to Cardiovascular Disease

Metabolic dysfunction-associated steatotic liver disease (MASLD) is associated with cardiovascular disease (CVD), sharing common risk factors, with a negative impact on patients' outcome. Cholesterol, and particularly its transport and accumulation in hepatic mitochondria by StARD1, contributes to the progression of MASH driven hepatocellular carcinoma due to the stimulation of the alternative mitochondrial bile acid synthesis pathway. 27-hydroxycholesterol (27-HC) is the most abundant circulating oxysterol derived from the metabolism of mitochondrial cholesterol by CYP27A1.