Abstract 2775 Unveiling the Role of Penicillin Binding Protein 4 in Hospital-Acquired Infections: Implications for Antibiotic Resistance and Treatment Strategies

Enterococcus faecium and Enterococcus faecalis are opportunistic pathogens with broad antibiotic resistance that pose a serious threat to human health. These pathogens are prevalent in hospital environments, where they cause bloodstream infections, soft-tissue infections, and urinary tract infections, primarily in immunocompromised patients who have undergone extensive prior antibiotic treatment. The combined antibiotic resistance and opportunistic nature of E. faecium and E. faecalis amplify their danger, targeting vulnerable populations and severely limiting effective treatment options.