Abstract 1508 ACAD10 and ACAD11 enable mammalian 4-hydroxy acid lipid catabolism
Background/Study Objective: Fatty acid β-oxidation (FAO) is a central catabolic pathway with broad implications for organismal health. However, various fatty acids are largely incompatible with FAO machinery before being modified by other enzymes. Such lipids include 4-hydroxy acids (4-HAs)-fatty acids hydroxylated at the 4 (γ) position-which can be provided from dietary intake, lipid peroxidation, and certain drugs of abuse. While the core enzymes of FAO were discovered several decades ago, the enzymes responsible for 4-HA catabolism in mammals remain unknown.
Authors
- Judith Simcox (ORCID: https://orcid.org/0000-0001-7350-6342)
- Daniel Amador‐Noguez (ORCID: https://orcid.org/0000-0002-3568-3070)
- David J. Pagliarini (ORCID: https://orcid.org/0000-0002-0001-0087)
- Raghav Jain (ORCID: https://orcid.org/0000-0002-1284-6762)
- Edrees H. Rashan (ORCID: https://orcid.org/0000-0002-3882-6655)
- Daven B. Khana (ORCID: https://orcid.org/0000-0002-8081-3436)
- Peng Yuan (ORCID: https://orcid.org/0000-0001-6492-0509)
- Jingying Zhang (ORCID: https://orcid.org/0009-0005-6130-2779)
- Abigail K. Bartlett
Institutions
- Oregon Institute of Technology (US)
Publication Details
- Journal
- Journal of Biological Chemistry
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1016/j.jbc.2025.109398
- Primary Topic
- Metabolomics and Mass Spectrometry Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00