Abstract 2392 Synthesis of a diacylglycerol analog near IR dye

Neutral lipids in mammalian cells are found in lipid storage droplets. Perilipin 5 is a lipid storage droplet protein, expressed predominantly in tissues with high oxidative metabolic activity, including the heart, muscle, and liver. Perilipin 5 plays a critical role in metabolic processes such as lipolysis, fatty acid storage, lipid droplet formation, and transport of lipids to mitochondria, therefore it is essential in maintaining metabolic homeostasis. AlphaFold predicts the structure of perilipin 5 to have a conserved hydrophobic pocket of unknown function.