Abstract 1773 A non-translational function of threonyl-tRNA synthetase in cancer cell proliferation through STAT3 activation
Aminoacyl-tRNA synthetases (aaRSs) are housekeeping proteins with an essential role in protein synthesis, but they are also known to have non-canonical/non-translational functions in a wide range of biological regulation. We find that the cytoplasmic threonyl-tRNA synthetase (TARS1) is overexpressed in many human cancers, and elevated TARS1 expression correlates with poor patient survival. In non-small cell lung cancer (NSCLC) cell lines, elevated TARS1 expression is found to contribute to cell proliferation.
Authors
- Erik A. Nelson
- R.B. Abdullah (ORCID: https://orcid.org/0009-0003-5672-5756)
- Mark Kei Fong Wong (ORCID: https://orcid.org/0000-0003-4146-9588)
- Shruti V. Bendre (ORCID: https://orcid.org/0000-0002-6391-8930)
- Adriana Reyes‐Ordoñez (ORCID: https://orcid.org/0000-0003-3482-3841)
- Pallob Barai (ORCID: https://orcid.org/0000-0002-0134-3860)
- Jie Chen (ORCID: https://orcid.org/0000-0002-7887-3747)
- Chong Dai
- Leah Lies
Institutions
- University of Nebraska–Lincoln (US)
- University of Illinois Urbana-Champaign (US)
Publication Details
- Journal
- Journal of Biological Chemistry
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1016/j.jbc.2025.110105
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00