Abstract 2182 Structure-guided analysis of a SEA domain in a model sensor glycoprotein that regulates signaling pathways: identification of sites impacting protein stability, trafficking, and function

Cells undergo highly dynamic processes, ranging from stress responses and cell cycle transitions to the reorganization of cell polarity during morphogenesis. Many of these processes are regulated by signal transduction pathways. When mis-regulated, these pathways can disrupt normal cell function leading to diseases such as cancers. Among the proteins that regulate signaling pathways are members of the diverse family of signaling glycoproteins, which include mucins, Notch, and Dystroglycan. Members of this family are single pass transmembrane proteins, with glycosylated extracellular domains and cytosolic domains that connect to signaling modules.