Abstract 1005 Mitotic Abnormalities in HPV+ Integrated Cervical and Intestinal Carcinomas by Histopathological Evaluation

The majority of cervical cancers are caused by the human papillomavirus (HPV), which also plays a major role in the development of various other cancers, including those of the head and neck, anal, vulvar, and penile regions. HPV causes chromosome instability through abnormal mitosis, leading to genomic instability, which is crucial for cancer development. This study sought to determine the spatial distribution of mitotic aberrations in HPV-positive integrated cervical carcinomas and compare chromosomal instability (CIN) caused by HPV to CIN in HPV-negative intestinal tissues, as CIN is a common feature of tumors.