Abstract 2213 Investigating binding of plantoside derivative compounds to penicillin binding protein (PBP)

The growing challenge of drug-resistant bacterial pathogens has heightened the urgency of discovering novel classes of antimicrobial compounds. Our research investigates the potential of plantoside derivatives as new antibiotics. These compounds possess a coumaroyl-based structure shown to inhibit bacterial growth, yet their molecular mechanism of action remains unclear. To explore their efficacy against common antibiotic resistance mechanisms, we aim to determine whether plantoside derivatives interact with Penicillin Binding Proteins (PBPs).