Abstract 1769 Elucidation of glutathione-related dipeptide metabolism in cancer
Amino acids promote tumor growth through multiple processes (i.e., protein biosynthesis, antioxidant production, energy generation). How tumors obtain their amino acids is poorly understood. The amino acids glutamate, cysteine, and glycine are components of a tripeptide glutathione (GSH), the most abundant antioxidant in mammalian cells. Recent studies have shown that antioxidants like GSH can increase tumor proliferation and metastatic progression. The exact mechanism behind antioxidants' impact on tumors is poorly understood.
Authors
- Gloria Asantewaa (ORCID: https://orcid.org/0000-0002-1420-4448)
- Fatemeh Alimohammadi
- Joshua Munger (ORCID: https://orcid.org/0000-0001-5379-9440)
- Fábio Hecht (ORCID: https://orcid.org/0000-0001-9110-2587)
- Emily Tuttle
- Isaac S. Harris (ORCID: https://orcid.org/0000-0002-6855-2763)
- Gina M. DeNicola (ORCID: https://orcid.org/0000-0001-6611-6696)
- Marco Zocchi (ORCID: https://orcid.org/0009-0001-3531-3045)
- Nancy E. Ward
Institutions
- University of Wisconsin–Parkside (US)
- University of Rochester Medical Center (US)
Publication Details
- Journal
- Journal of Biological Chemistry
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1016/j.jbc.2025.109487
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health