Abstract 2311 Impact of N-terminal Truncations on the Antimicrobial Activity and Mechanism of DesHDAP1
Antimicrobial resistance is one of the top 10 global public health threats, responsible for 5 million deaths per year, according to the World Health Organization. In addition to efforts to curb antimicrobial resistance through coordinated antibiotic stewardship, new effective drug compounds must also be developed, such as antimicrobial peptides (AMPs). Our lab previously designed DesHDAP1, a histone-derived antimicrobial peptide (HDAP) based on histone H2A. In this study, we considered the activity and mechanism of DesHDAP1 variants systematically truncated from the N- and C- termini.
Authors
- Louise E.O. Darling (ORCID: https://orcid.org/0000-0002-7798-8024)
- Donald E. Elmore (ORCID: https://orcid.org/0000-0002-8723-8710)
- Anne K. Buck (ORCID: https://orcid.org/0009-0003-2107-3946)
- Kerry Gao
- Anna Hepfer
- Margaret Babikian
Institutions
- Rutgers, The State University of New Jersey (US)
- Wellesley College (US)
Publication Details
- Journal
- Journal of Biological Chemistry
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1016/j.jbc.2025.109066
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases