Metastatic Hepatocellular Carcinoma Presenting as a Large Abdominal Mass and Secondary Varicocele in a Hepatitis B Patient: A Case Report

We report a rare and aggressive presentation of hepatocellular carcinoma in a 50-year-old man with a brief history of hepatitis B infection. The patient presented with a rapidly enlarging epigastric mass, recurrent hematemesis, and a newly developed left-sided varicocele. Imaging revealed a large exophytic hepatic mass with evidence of vascular displacement and intrahepatic metastases. Histopathological examination confirmed a diagnosis of poorly differentiated hepatocellular carcinoma. A multidisciplinary tumor board recommended palliative surgical debulking followed by systemic therapy to address tumor burden and improve quality of life. This case highlights the diagnostic and management challenges associated with atypical presentations of hepatocellular carcinoma in patients with minimal liver disease history.

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Journal
Cureus
Published
2025-06-13
DOI
https://doi.org/10.7759/cureus.85933
Primary Topic
Hepatocellular Carcinoma Treatment and Prognosis
Type
article
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article

Metastatic Hepatocellular Carcinoma Presenting as a Large Abdominal Mass and Secondary Varicocele in a Hepatitis B Patient: A Case Report

Danish Abbasi, Muhammad Hamza Shahid, Murugesan Manoharan, Abdul Haseeb Hasan et al.
Cureus
Hepatocellular Carcinoma Treatment and Prognosis
article

Metastatic Hepatocellular Carcinoma Presenting as a Large Abdominal Mass and Secondary Varicocele in a Hepatitis B Patient: A Case Report

Danish Abbasi, Muhammad Hamza Shahid, Murugesan Manoharan, Abdul Haseeb Hasan, Lohana Pooja
article en

Abstract

We report a rare and aggressive presentation of hepatocellular carcinoma in a 50-year-old man with a brief history of hepatitis B infection. The patient presented with a rapidly enlarging epigastric mass, recurrent hematemesis, and a newly developed left-sided varicocele. Imaging revealed a large exophytic hepatic mass with evidence of vascular displacement and intrahepatic metastases. Histopathological examination confirmed a diagnosis of poorly differentiated hepatocellular carcinoma. A multidisciplinary tumor board recommended palliative surgical debulking followed by systemic therapy to address tumor burden and improve quality of life. This case highlights the diagnostic and management challenges associated with atypical presentations of hepatocellular carcinoma in patients with minimal liver disease history.

CureusVol. 17(6)
Karachi Medical and Dental College (PK), Liaquat University of Medical & Health Sciences (PK), CMH Lahore Medical College and Institute of Dentistry (PK), Farooq Hospital (PK), Mayo Hospital (PK)
Good health and well-being
Openalex Percentile: Top 80%
Hepatocellular Carcinoma Treatment and Prognosis
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Metastatic Hepatocellular Carcinoma Presenting as a Large Abdominal Mass and Secondary Varicocele in a Hepatitis B Patient: A Case Report — Danish Abbasi, Muhammad Hamza Shahid, et al. · Cureus (2025) | TGRS Research Map | TGRS