Abstract 1567 Acetyl-CoA metabolism drives the secretory phenotype in oncogene-induced senescence
Oncogenic activation is involved in cancer initiation and development, and is known for promoting cell proliferation. However, it can also induce premature cell senescence, a state characterized by proliferation arrest and acquisition of a senescence-associated secretory phenotype (SASP). Senescent cells secrete growth factors, chemokines, cytokines, proteases and other factors, that can impact on the cell's microenvironment influencing tumor progression. Metabolic alterations are one of the hallmarks of cellular senescence and several metabolic pathways are required to maintain the SASP.
Authors
- Toren Finkel (ORCID: https://orcid.org/0000-0002-0726-3546)
- Santiago Ruiz (ORCID: https://orcid.org/0000-0002-2626-6160)
- Santiago Mansilla (ORCID: https://orcid.org/0000-0002-3208-9981)
- Inés Marmisolle
- Laura Castro (ORCID: https://orcid.org/0000-0002-5771-7630)
- Carlos Escande (ORCID: https://orcid.org/0000-0002-9611-0903)
- Celia Quijano (ORCID: https://orcid.org/0000-0001-9254-7123)
- Jie Liu (ORCID: https://orcid.org/0000-0003-0451-6111)
- Eliana Chacón
Institutions
- Universidad San Pablo (MX)
Publication Details
- Journal
- Journal of Biological Chemistry
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1016/j.jbc.2025.109478
- Citations
- 1
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- Agencia Nacional de Investigación e Innovación
- Universidad de la República Uruguay
- Comisión Sectorial de Investigación Científica