Abstract 1903 Assessing the Retention of a Hydroxyapatite-Binding Peptide in Live Tissues

One in eight women are diagnosed with breast cancer, and between 20 and 30% of these diagnoses will become metastatic1,2. Bone metastases are the most common type of metastasis in breast cancer, and these occur when the cancerous cells from the breast tissue enter the blood circulation and migrate to bones. The current standard of care for bone metastasis is chemotherapy, hormonal therapy, and immunotherapy, with increasing interest in targeted therapies3. The pitfall of these treatments is that they are systemic, damaging healthy cells and cancer cells alike.

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Publication Details

Journal
Journal of Biological Chemistry
Published
2025-05-01
DOI
https://doi.org/10.1016/j.jbc.2025.109046
Primary Topic
Radiopharmaceutical Chemistry and Applications
Type
article
Field-Weighted Citation Impact
0.00
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article

Abstract 1903 Assessing the Retention of a Hydroxyapatite-Binding Peptide in Live Tissues

Philip Stewart Low, Linda J. Jung, Lauren Thompson
Journal of Biological Chemistry
Radiopharmaceutical Chemistry and Applications
article

Abstract 1903 Assessing the Retention of a Hydroxyapatite-Binding Peptide in Live Tissues

Philip Stewart Low, Linda J. Jung, Lauren Thompson
article en

Abstract

One in eight women are diagnosed with breast cancer, and between 20 and 30% of these diagnoses will become metastatic1,2. Bone metastases are the most common type of metastasis in breast cancer, and these occur when the cancerous cells from the breast tissue enter the blood circulation and migrate to bones. The current standard of care for bone metastasis is chemotherapy, hormonal therapy, and immunotherapy, with increasing interest in targeted therapies3. The pitfall of these treatments is that they are systemic, damaging healthy cells and cancer cells alike.

Journal of Biological ChemistryVol. 301(5)
Purdue University West Lafayette (US)
Zero hunger
Openalex Percentile: Top 79%
Radiopharmaceutical Chemistry and Applications
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