Abstract 1731 Evaluating Pterostilbene's Role in Mitigating NOX-Driven Oxidative Stress in Endothelial Cells Under Hyperglycemic Conditions

Diabetes is a common chronic condition that can lead to serious complications, such as diabetic kidney disease. When glucose levels rise, it triggers an increase in NADPH Oxidase (NOX) expression, which in turn promotes the production of reactive oxygen species (ROS) and accelerates cellular proliferation. Pterostilbene, known for its antioxidant properties, has been shown to effectively reduce oxidative stress in various cell types. This study aims to investigate the NOX pathways in endothelial cells under hyperglycemic conditions and evaluate the potential of pterostilbene to mitigate oxidative stress.