Abstract 2230 Role of the Candida albicans SPFH Proteins in Surfactant Stress Tolerance and Antifungal Drug Resistance

The SPFH (Stomatin, Prohibitin, Flotillin, HflK/HflC) protein superfamily is conserved across all domains of life. Fungal SPFH proteins are required for respiration, stress adaptation, and membrane scaffolding. In the yeast, Candida albicans, stomatin-like protein 3 (Slp3) forms punctate foci at the plasma membrane, and SLP3 over-expression causes cell death following exposure to the surfactant, sodium dodecyl sulfate (SDS), and the oxidative stressor, H2O2. Here, we sought to determine the cellular localization and functionally characterize stomatin-like protein 2 (Slp2), prohibitin-1 (Phb1), prohibitin-2 (Phb2), and prohibitin-12 (Phb12) in C.