Abstract 2251 Neuromodulatory mechanisms of social isolation lead to pain and impaired cognition in sickle cell disease mice

Sickle cell disease (SCD) is an inherited autosomal recessive disorder of the ß-globin gene resulting in sickle hemoglobin (HbS). Chronic pain, cognitive impairment, and inflammation are common features of SCD. Social determinants of health (SDOH) may affect the whole individual by altering the perception-based stimuli contributing to impaired cognition, pain and poor therapeutic outcomes. Social isolation may therefore contribute to worsening of chronic pain and may interfere with treatment. Presently, the central and peripheral mechanisms underlying SDOH impacts on SCD are not understood.