An exploratory analysis of driver gene alterations and their potential prognostic relevance in endometrial cancer with POLE exonuclease domain mutations
This exploratory study finds that POLE exonuclease domain mutations are associated with distinct mutational patterns that vary between tumor suppressor genes and oncogenes. These observations provide hypothesis-generating insights into potential mechanisms underlying the favorable prognosis of POLEmut tumors and may inform future molecular investigations in endometrial cancer.
Authors
- Dar-Bin Shieh (ORCID: https://orcid.org/0000-0001-9389-4194)
- Chao-Chih Wu (ORCID: https://orcid.org/0000-0001-7280-2342)
- Tsai‐Yin Wei (ORCID: https://orcid.org/0000-0001-5738-2407)
- Wen-Hsuan W. Lin (ORCID: https://orcid.org/0000-0002-5414-7900)
- Chih-Long Chang
- Yun-Ting Hsu (ORCID: https://orcid.org/0000-0002-2829-4560)
- Li‐Chu Tsai
Institutions
- National Taipei University of Technology (TW)
- Mackay Memorial Hospital (TW)
- Mackay Medical University (TW)
- National Cheng Kung University Hospital (TW)
- National Cheng Kung University (TW)
Publication Details
- Journal
- Gynecologic Oncology
- Published
- 2025-06-13
- DOI
- https://doi.org/10.1016/j.ygyno.2025.06.006
- Citations
- 1
- Primary Topic
- Cancer Genomics and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 0.94