Abstract 2095 Redox shifts in the cysteine proteome in response to sulfide

The colon is an environment rich in hydrogen sulfide (H2S), which can be endogenously derived from dietary intake of methionine. High dietary sulfur intake and elevated H2S are associated with increased incidence of diseases of the lower gut like inflammatory bowel disease and colon cancer, highlighting a potential role of sulfur metabolism in the pathology of digestive diseases. Our lab has shown that mice fed a methionine rich diet (MRD) increase production of downstream sulfide oxidation product thiosulfate, and have depletion of mucus-secreting goblet cells in colon.