Abstract 2444 The role of the glycine-rich region of class B J-domain proteins in the interaction with Hsp70

Molecular chaperone systems, composed of Hsp70 and J-domain proteins (JDPs), are fundamental for the quality control of virtually all other proteins in the cell. In the current model, the more structurally and functionally diverse JDPs act as cochaperones, recruiting a multifunctional molecular chaperone, Hsp70, to support various biological activities. Among the three classes of JDPs, class B representatives are unique, not only due to their essential yet unknown function but also because of their ability to recruit Hsp70 for fragmentation of amylogenic-like protein fibrils found in human neurodegenerative diseases such as Alzheimer's or Parkinson's.