Abstract 2854 Spatial analysis of neuronal p-tau protein aggregation post-axonal injury: a basis for the understanding of tauopathy progression

Tauopathies are neurodegenerative diseases identified by aggregation of hyperphosphorylated tau (p-tau) protein deposits in the brain. These “neurofibrillary tangles” are the root cause of many neurological disorders, such as Pick's disease, frontotemporal dementia, and chronic traumatic encephalopathy, and are a defining factor in the development of the neuritic plaques that cause Alzheimer's disease. While the role of p-tau in tauopathies is quite well understood, the process in which hyperphosphorylation and aggregation of the protein occurs is yet to be fully elucidated.