Abstract 2804 From Nitrite to Ammonia: The Role of Cytochrome c Nitrite Reductase (NrfA)
Nitrate and nitrite are serious contaminants of waterways that can lead to eutrophication. Certain organisms, however, can convert nitrate and nitrite to ammonium via the dissimilatory nitrate reduction to ammonium (DNRA) pathway. One of the enzyme complexes capable of performing DNRA is comprised of two proteins: NrfH, a membrane-bound quinol oxidase, and its redox partner NrfA, a soluble periplasmic nitrite ammonifier. NrfA catalyzes the six-electron, eight-proton reduction of nitrite to ammonium and helps retain nitrogenous nutrients in the soil.
Authors
- Krystina Hird
- Nicolai Lehnert (ORCID: https://orcid.org/0000-0002-5221-5498)
- Sean J. Elliott (ORCID: https://orcid.org/0000-0003-0096-9551)
- Eric L. Hegg (ORCID: https://orcid.org/0000-0003-2055-5495)
- Michaël Tracy
- Ekaterina V. Pletneva (ORCID: https://orcid.org/0000-0003-1380-2929)
- Fangfang Zhong (ORCID: https://orcid.org/0000-0002-8168-6424)
- Cybele Lemuh Njimoh (ORCID: https://orcid.org/0009-0000-7200-1828)
Publication Details
- Journal
- Journal of Biological Chemistry
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1016/j.jbc.2025.110032
- Primary Topic
- Metabolism and Genetic Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Rensselaer Polytechnic Institute
- National Institutes of Health