Abstract 1952 Gender discrepancies in Alzheimer's disease (AD) pathogenesis: the role of MSRB enzyme

Aging is one of the most significant risk factors for Alzheimer's disease (AD). Recent studies have also shown that gender is another critical factor since females account for 60% of AD patients. Oxidative damage and mitochondrial dysfunction have been demonstrated as major contributing factors for AD. The methionine (Met) sulfoxide reductase (MSR) family of enzymes, comprised of MSRA and MSRB1, MSRB2, and MSRB3, play an important role against oxidative damage by reducing oxidized Met residues in proteins, which can restore protein function and also permit Met residues in proteins to function as ROS scavengers.