Abstract 1488 CTCF knockdown rescues the MAPK signaling pathway in Vezf1 null murine embryonic stem cells

Embryonic stem cells (ESCs) are a unique cell line that retains pluripotency. Once the ESCs are triggered by certain chemical processes, they start to undergo differentiation, which ultimately leads to the development of three embryonic germ lines in a developing embryo. Mitogen-activated protein kinase (MAPK) cascades encompass different signaling pathways and play a critical role in embryonic development. MAPK signaling has been shown to play a role in promoting the differentiation of ESCs and regulating the pluripotency of stem cells.