Abstract 2908 Imaging and Absolute Quantification of RNA nanoparticles in eye tissue

Effective ocular drug delivery for treating chronic posterior eye diseases remains challenging. RNA nanoparticles, with defined size and shape, could be used as vectors to enhance delivery for RNA-based therapeutics. Moreover, they can be fabricated to allow simultaneous targeting and/or delivery of multiple therapeutic and targeting ligands. Consequently, this could be used to achieve synergistic drug delivery and therapy effects. This study was performed on 10 nm square shaped RNA nanoparticles (SQR-NPs).