Abstract 1275 Synucleinopathies: Molecular Determinants of β-Synuclein and γ-Synuclein Toxicity in a Yeast Model

Synucleinopathies, a group of disorders characterized by the abnormal folding and aggregation of proteins from the synuclein family (including α-, β-, and γ-synuclein), encompass Parkinson's Disease (PD), the second most prevalent neurodegenerative condition. While α-synuclein's role in PD is well-researched, less is understood about the involvement of β- and γ-synucleins in neurodegeneration and toxicity. However, two mutations in β-synuclein (P123H and V70M) are associated with Dementia with Lewy Bodies (DLB), and γ-synuclein inclusions are linked with ALS pathology.