Abstract 1476 Phage Therapy: A Complementary Approach to Treat Bacterial Infections

Phage therapy is an emerging strategy for treating bacterial infections. It uses bacterial viruses, or phages, to specifically target harmful bacteria while leaving others unaffected due to their host specificity. The overuse of antibiotics has contributed to the rise of antibiotic-resistant strains, posing significant challenges to public health. It has also led to unintended consequences, like microbiome disruptions that increase risks for allergies and immune issues. Phage therapy is gaining traction as a complementary approach to antibiotic therapy, especially for multidrug-resistant pathogens like the ESKAPE group (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species), which are notorious for their ability to evade antibiotics.

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Publication Details

Journal
Journal of Biological Chemistry
Published
2025-05-01
DOI
https://doi.org/10.1016/j.jbc.2025.109595
Primary Topic
Bacteriophages and microbial interactions
Type
article
Field-Weighted Citation Impact
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article

Abstract 1476 Phage Therapy: A Complementary Approach to Treat Bacterial Infections

John J. Dennehy, A.L. Jaime, Mónica Trujillo, Victoria Irizarry
Journal of Biological Chemistry
Bacteriophages and microbial interactions
article

Abstract 1476 Phage Therapy: A Complementary Approach to Treat Bacterial Infections

John J. Dennehy, A.L. Jaime, Mónica Trujillo, Victoria Irizarry
article en

Abstract

Phage therapy is an emerging strategy for treating bacterial infections. It uses bacterial viruses, or phages, to specifically target harmful bacteria while leaving others unaffected due to their host specificity. The overuse of antibiotics has contributed to the rise of antibiotic-resistant strains, posing significant challenges to public health. It has also led to unintended consequences, like microbiome disruptions that increase risks for allergies and immune issues. Phage therapy is gaining traction as a complementary approach to antibiotic therapy, especially for multidrug-resistant pathogens like the ESKAPE group (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species), which are notorious for their ability to evade antibiotics.

Journal of Biological ChemistryVol. 301(5)
Queensborough Community College, CUNY (US)
Zero hunger
Openalex Percentile: Top 86%
Bacteriophages and microbial interactions
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Abstract 1476 Phage Therapy: A Complementary Approach to Treat Bacterial Infections — John J. Dennehy, A.L. Jaime, et al. · Journal of Biological Chemistry (2025) | TGRS Research Map | TGRS