Abstract 1245 Resveratrol a Novel Therapeutic Agent against Pancreatic Neuroendocrine Tumors

Pancreatic neuroendocrine tumors (pNETs) are rare slow growing cancers of the pancreas that are aggressive and deadly. Surgical resection is still the only curative therapeutic option for localized pNETs. Recurrence is however common and such patients progress towards highly aggressive disease with poor prognosis. We propose that non-toxic drugs that can restrict tumor recurrence and progression without impacting the overall quality of life could be ideal form of therapy for pNET patients who often live symptomless for extended periods of time.

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Publication Details

Journal
Journal of Biological Chemistry
Published
2025-05-01
DOI
https://doi.org/10.1016/j.jbc.2025.109020
Primary Topic
Calcium signaling and nucleotide metabolism
Type
article
Field-Weighted Citation Impact
0.00
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article

Abstract 1245 Resveratrol a Novel Therapeutic Agent against Pancreatic Neuroendocrine Tumors

Dingqiang Zhang, Irfana Muqbil
Journal of Biological Chemistry
Calcium signaling and nucleotide metabolism
article

Abstract 1245 Resveratrol a Novel Therapeutic Agent against Pancreatic Neuroendocrine Tumors

Dingqiang Zhang, Irfana Muqbil
article en

Abstract

Pancreatic neuroendocrine tumors (pNETs) are rare slow growing cancers of the pancreas that are aggressive and deadly. Surgical resection is still the only curative therapeutic option for localized pNETs. Recurrence is however common and such patients progress towards highly aggressive disease with poor prognosis. We propose that non-toxic drugs that can restrict tumor recurrence and progression without impacting the overall quality of life could be ideal form of therapy for pNET patients who often live symptomless for extended periods of time.

Journal of Biological ChemistryVol. 301(5)
Lawrence Technological University (US)
Zero hunger, Good health and well-being
Openalex Percentile: Top 85%
Calcium signaling and nucleotide metabolism
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