Abstract 1324 Progress Toward the Development of Nanobodies Targeting the Moonlighting Activity of S. aureus GAPDH via Directed Evolution

Antibiotic resistance poses a substantial global threat to human health in all parts of the world. New resistance mechanisms are emerging and spreading globally. These mechanisms jeopardize our ability to combat common infectious diseases and necessitate new strategies for developing antimicrobial compounds. A potential strategy for developing new antibiotics is to target virulence factors, which can have several advantages over traditional antibiotics, such as targeting pathogenic bacteria in preference to commensal bacteria.