Mitochondrial sirtuin 4 shapes the intestinal microbiota of Drosophila by controlling lysozyme expression
The only mitochondrial sirtuin in Drosophila, dSirt4, is induced by dietary stress in intestinal epithelial cells, which directly regulates the lysozyme activity of these cells. We could associate this altered lysozyme activity with a shift in the microbiota composition, demonstrating a direct link between stress, nutrition, and the host's microbiota regulation.
Authors
- Shauni Doms (ORCID: https://orcid.org/0000-0002-2129-4138)
- Ronald P. Kühnlein (ORCID: https://orcid.org/0000-0003-1448-4117)
- Christian Treitz (ORCID: https://orcid.org/0000-0001-7500-9083)
- Judith Bossen (ORCID: https://orcid.org/0000-0002-6604-4570)
- Iris Bruchhaus (ORCID: https://orcid.org/0000-0002-3363-7409)
- Jakob von Frieling (ORCID: https://orcid.org/0009-0004-4428-9333)
- Andreas Tholey (ORCID: https://orcid.org/0000-0002-8687-6817)
- Thomas Roeder (ORCID: https://orcid.org/0000-0002-3489-3834)
- Mirjam Knop (ORCID: https://orcid.org/0009-0002-2530-9701)
- Stina Bettendorf
- John F. Baines
- Abdulgawaad Saboukh
Institutions
- University of Graz (AT)
- Hochschule für Angewandte Wissenschaften Kiel (DE)
- Christian-Albrechts-Universität zu Kiel (DE)
- BioTechMed-Graz (AT)
- German Center for Lung Research (DE)
- Max Planck Institute for Evolutionary Biology (DE)
- Clinical Research Center Kiel (DE)
- Bernhard Nocht Institute for Tropical Medicine (DE)
Publication Details
- Journal
- Animal Microbiome
- Published
- 2025-06-13
- DOI
- https://doi.org/10.1186/s42523-025-00431-x
- Primary Topic
- Genetics, Aging, and Longevity in Model Organisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Deutsche Forschungsgemeinschaft
- Christian-Albrechts-Universität zu Kiel
- Karl-Franzens-Universität Graz
- Leibniz-Gemeinschaft