Abstract 1432 Elevated Carbon Dioxide Levels Suppress Protein Translation and Modulate Canonical and Non-Canonical Signaling Pathways in Lung Epithelial Cells

Introduction: Hypercapnia, characterized by elevated carbon dioxide (CO2) levels in blood and tissues, is a frequent complication of acute and chronic pulmonary diseases. It disrupts cellular growth and proliferation and impairs anabolic processes, which are critical for tissue repair and function. Protein translation, a key component of global protein synthesis, plays a pivotal role in these disturbances. This study investigates the impact of hypercapnia on protein translation in lung epithelial cells and tissues.