Abstract 2085 Atomic-level insights into the roles of the intrinsically disordered proteins c-Myc and CITED2 in regulating gene expression

Intrinsically disordered proteins (IDPs) are involved in a variety of cellular processes such as the regulation of signaling, transcription, translation, and the cell cycle. Due to their involvement in key cellular processes, IDPs are implicated in many diseases, including cancer. A common feature of IDP interactions is multivalency, which describes the presence of multiple binding sites on an IDP for various binding partners. One example of a multivalent IDP is CITED2, a fully disordered transcriptional regulator that plays a role in cell proliferation, apoptosis, and differentiation, and has been implicated in numerous cancers.