Abstract 1693 The oxygen sensing c-di-GMP metabolic enzymes DosC and DosP affect stress tolerance and metabolism in Escherichia coli

Sensing and responding to O2 is an essential process for many bacteria, and O2 levels are linked to many pathways and phenotypes, such as metabolism, stress tolerance, motility, and virulence. One way through which the facultatively anaerobic bacterium Escherichia coli responds to environmental O2 is through the O2-sensing cyclic-di-GMP metabolic complex, DosCP. DosC synthesizes cyclic-di-GMP, while DosP breaks it down, and both proteins modulate their activity in response to changes in O2 levels.