Abstract 2363 Probing the function of the 265-290 loop of perilipin 5

Central to numerous modern health concerns is excessive or aberrant lipid storage. Nearly all cells store neutral lipids in organelles termed lipid storage droplets. Perilipin 5 is a lipid storage droplet protein with several established roles in triacylglycerol metabolism. The perilipin 5 sequence is highly conserved with perilipin 3 and both are thought to share several important structural features. One of these is a four-helix bundle with a mixed alpha-beta structure which resembles a boot. At the top of the four-helix bundle is a short loop structure we have termed the 265-290 loop.