Abstract 2688 Proximity labeling uncovers a novel putative role for spinophilin as a mediator of dendritic protein homeostasis

Unlike their kinase counterparts, serine/threonine phosphatases obtain substrate specificity and regulated activity in part via protein complexes. This is highly evident with protein phosphatase 1 (PP1) which complexes with over 200 regulatory and / or targeting proteins. Spinophilin is the major postsynaptic density (PSD)-associated PP1 targeting protein. We have found that loss of spinophilin within the striatum impacts motor output and motor function both basally and in the context of perturbed striatal function.