Abstract 1844 Lamp1 deficiency disrupts lipid transport in Drosophila

Lysosomes play an important role in cell homeostasis through the degradation and recycling of macromolecules. Many neurodegenerative diseases have been linked to defective lysosomes. Lysosome-associated membrane proteins, LAMP1 and LAMP2 in humans, have been well characterized for their role in autophagy and cholesterol transport in vertebrates, which play a role in the organism's viability. Recently, analysis of the LAMP ortholog in Drosophila melanogaster, Lamp1, showed that Lamp1 mutant 3rd instar larvae accumulate diacylglycerols with mid-chain fatty acids (mcDAGs) and sterols.